Parkinson Pipeline Project

The Pipeline Project Needs Your Help

What's New...

Opinion: Is there an important pattern in the seemingly uninterrupted failure of drugs and biologics?
Read this Op/Ed

On the Toxicity of GDNF:
A challenge to Amgen's monkey GDNF toxicity study

Book: "Monkeys in the Middle: How One Drug Company Kept a Parkinson's Disease Breakthrough Out of Reach" by investigative journalist Nick Nelson, has just been published and is available on Amazon.

The "Access, Compassion, Care, and Ethics for Seriously Ill Patients Act"
or the Access Act (S3046 ) was introduced in the Senate in May. It is a bill to amend the Federal Food, Drug, and Cosmetic Act to create a new conditional approval system for drugs, biological products, and devices that is responsive to the needs of seriously ill patients, and for other purposes. For Details see Library of Congress, Thomas

Past What's New items have been archived on
this page.

The Parkinson Pipeline
Project is supported by
the Parkinson's Disease Foundation (PDF),
a 501(c)3 Corporation headquartered in New York City.

Tax deductible donations to the Parkinson Pipeline Project, made through this website to Donate.net, go
to the PDF designated for use by the Parkinson Pipeline Project.

What is the Pipeline Project?

The Parkinson Pipeline Project is a grassroots group of advocates whose goal is to provide the patient perspective in the treatment development process. Through education, consultation, and participation with all stakeholders - including industry and the FDA - the Parkinson Pipeline Project hopes to increase clinical trial participation and accelerate approved treatment options. New PD treatments are followed from pre-clinical development to approval in the Pd Pipeline Database found on our website. More info...

"The missing ingredient in the development of new therapies is the voice of the patient."

Perry Cohen, Ph.D.,
Project Director

Declaration of Clinical Research Rights and Responsibilities
for People With Parkinson’s

Clinical research is essential to the development of new therapies and treatments for Parkinson’s disease. Yet, due to a number of factors, including a lack of awareness and understanding of the research process, only one percent of people with Parkinson’s participate. This is far below the number needed, delaying many promising trials. Read the entire Declaration!

"Ethical Issues in Clinical Neuroscience Research: A Patient's Perspective"

Written by Parkinson Pipeline Project members
Published in Neurotherapeutic, Vol. 4, No. 3, 2007.
Read the article

To access PD Pipeline database records related to these news items - please click on

Orally Disintegrating Selegiline (Zelapar) Allows Parkinson's Disease Patients to Lower Dopamine Agonist Dose (6/27/08) Read press release

Spheramine - Titan's potential cell-based treatment for Parkinson's Disease "failed in a Phase IIb study, and likely won't be continued by partner Bayer Schering Pharma. " Read article. (7/2/08)

"Understanding the Recent Announcement about Azilect® and its Potential to Slow the Progression of Parkinson’s Disease" Statement from the Parkinson's Disease Foundation (PDF) Read statement.

Teva Pharmaceutical Industries Ltd. announced the successful completion of ADAGIO, the phase III study designed to demonstrate that AZILECT 1 mg tablets can slow down the progression of Parkinson's disease." (6/15/08) Read full press release

FDA approval received for Requip XL 24-Hour - once- a-day dopamine agonist (6/1/3/08) Read press release

Kyowa Pharmaceutical Suspends Development of Istradefylline (KW-6002) in North America. Read sponsor's letter to the PD community (6/3/08) Read press release

Kyowa Hakko Kogyo Co., Ltd. (President: Dr. Yuzuru Matsuda) announced that Kyowa Pharmaceutical, Inc. (New Jersey, United States), its wholly owned U.S. subsidiary, received on February 25, 2008 (local time) a Not approvable letter from the

U.S. Food and Drug Administration (FDA) for istradefylline (KW-6002), its investigational drug for the treatment of Parkinson's disease. Read press release

Metabolomic Profiling to Develop Blood Biomarkers for Parkinson's Disease (06/08)

Can We Prevent Parkinson's Disease With N-3 Polyunsaturated Fatty Acids? Read the full article - In four parts

FDA Scraps Helsinki Declaration on Protecting Human Subjects" Read full opinion

FDA Signals High Bar for Stem Cell Treatments. Read full article and comments in Wall Street Journal Health Blog.

UCB advises US-physicians to down-titrate patients on Neupro(R) in view of out-of-stock situation in the US. UCB initiates recall of Neupro(R) batches, which will lead to an out-of-stock situation in the United States in late April. Patients in the US are advised to contact their healthcare provide) r. Neupro(R) supply is sufficient in other regions. Read press release (3/20/08)
Update on Neupro Recall (4/21/08)

Supreme Court Declines to Hear Case on Access to Experimental Medications for Terminally ill Patients Read the full article (Jan 17, 2008)

When Registering Trials is No Help by Merrill Goozner, from GoozNews blog, March 7 2008
Read article

Gains Come with Risks, Sometimes Personal Costs by Peggy Willocks

Profit Over Common Sense
Andy Grove Speaks to Society for Neuroscience

New data has patient advocates still asking: Why did Amgen halt its GDNF trials?
Given the overwhelmingly positive phase I trial results, and the inconclusive results of the phase II trial, the research should have been continued.

Tell Us What You Think

Your access to and use of the information contained in this web site is subject to this Terms and Conditions of Use Agreement. By accessing and using this web site, you accept this Terms and Conditions of Use Agreement.

The contents of this website and all communications with Parkinson Pipeline Project (PPP) are solely for information purposes and are not intended as medical advice. While we make every effort to assure that the information is accurate and up to date, an error may >occasionally occur. All information and materials are provided AS IS without any warranty of any kind. In no event will the PPP be held liable for any damages arising out of information contained in our website.

If any provision of this Terms and Conditions of Use Agreement is held to be unlawful, void, or unenforceable, then such provision shall be deemed severed without affecting the enforceability of all remaining provisions.