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Well, not everybody went home. Some people were persistent enough to look at the reasons, took the possible golden nugget to see what went wrong, and did a study in animal models that concluded with the comment that
They used radioactive tracers. I replotted the radioactive tracers distribution on a semilog plot. Those red dots are the relative concentration as a function of the distance from the source. The distance from the source is measured in millimeters.
And I looked at this thing and say: I've seen that curvature. That curvature is a diffusion curve. I go back to my books, look up the diffusion curve, plot it and it does look like the data. If it was convection, the concentration would be much more even. So the data do not look like convection. A more recent experiment will give you further indications of that.
The target areas are indicated in red. The cannulas which you can’t see, are the two vertical lines. One of them, it turns out, misses the target area. The other one doesn't. What happens when we look at the video of putting an MRI observable tracer is that we see completely different behavior between the two sides. This is representative of many, many observations, now that this kind of MRI observation can be done intra-procedurally. And we find that sometimes we get this, other times we get that, and God knows why one thing or another. We certainly don't know in advance. We can hypothesize afterwards, but hypothesizing afterwards is nothing short of conjecture, and my conclusion is that convection is not much more than conjecture.
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Copyright © 2004-2009 Parkinson Pipeline Project. All rights reserved. Revised: 02/24/11. |